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IGRT Credentialing for NCI Sponsored Clinical Trials

A Molineu*, P Chi , J Lowenstein , D Followill , UT MD Anderson Cancer Center, Houston, TX


(Sunday, 7/29/2018) 3:00 PM - 6:00 PM

Room: Exhibit Hall

Purpose: To credential institutions participating in NCI sponsored clinical trials for IGRT.

Methods: Institutions can be approved for either boney anatomy or soft tissue anatomy IGRT. They are asked to submit IGRT datasets for two fractions from either a HN or brain case (for boney anatomy) and a lung, liver or pancreas case (for soft tissue anatomy.) All sites must also submit data for a pelvis case. The data is submitted through TRIAD in DICOM format and should include the planning CT, RT structure set, RT plan file, RT dose file, localization images used (CBCT, kVCT, etc), and the spatial registration file if available. The sites also submit a questionnaire where they are asked to describe their IGRT procedures and QA. Once the submission is complete, the items are reviewed in MIM Maestro®.

Results: 146 submissions have been received, of which 20 are incomplete. 125 approvals have been issued: 82 for boney and soft tissue anatomy, 33 for soft tissue only, and 10 for boney only. 108 approvals are for c-arm type machines. The rest are for CyberKnife (10), proton (5) and TomoTherapy (2). One site did not receive approval due to lacking a comprehensive IGRT procedure. Several sites have clarified or improved their procedures based on feedback from the review. Common questions for the site include asking about bladder fill for pelvic irradiations, asking for clarification on procedures for re-imaging after applying shifts, and asking for clarification about scan-range procedures.

Conclusion: IGRT credentialing ensures that institutions participating in NCI sponsored clinical trials have an IGRT QA program and can capture and register images that exhibit an appropriate field of view and quality.

Funding Support, Disclosures, and Conflict of Interest: This work is sponsored by NCI grant CA180803.


Image Guidance, Clinical Trials


IM/TH- Formal quality management tools: General (most aspects)

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