Room: Exhibit Hall | Forum 9
Purpose: We have previously demonstrated that electronic tissue compensation (eComp) was the preferred radiotherapy technique to decrease skin dose for breast cancer patients with larger than 22.5 cm breast separation (BS). Based on this anatomic feature, in the present study, we evaluated the acute skin toxicity of the eComp technique compared to three-dimensional radiotherapy (3DCRT).
Methods: A total of 69 breast cancer patients with stage 0-II and larger than 22.5 cm BS were treated with breast-conserving surgery (BCS) followed by whole breast irradiation (WBI). All patients underwent treatment planning computed tomography before WBI. Of the 69 patients, 35 (50.7%) were treated with eComp, and the 34 patients (49.3%) were treated with 3DCRT. Baseline photographs before RT and weekly photographs during radiotherapy were taken for further review. Acute skin toxicity was assessed for all patients each week during and up to 6 weeks after radiotherapy.
Results: EComp significantly reduced the acute Grade 2 dermatitis as compared to 3DCRTï¼ˆ42.9% vs. 67.6%, P=0.038ï¼‰.No patient experienced Grade 3 dermatitis in eComp group but 2 patients did in 3DCRT group. No difference was found in breast edema between the two groups (P=0.754). eComp resulted in reduced Grade 3 breast pain (11.4% vs. 35.3%, P=0.019). A multivariate analysis found the use of eComp (P=0.045) and smaller BS (P=0.026) were significantly associated with a decreased risk of dermatitis. The use of eComp correlated with reduction of breast pain (P=0.036).
Conclusion: The use of eComp in those patients larger than 22.5 cm breast separation (BS) with the treatment of the whole breast results in a significant decrease in acute skin toxicity compared to 3DCRT.
Funding Support, Disclosures, and Conflict of Interest: This study was supported by National Natural Science Foundation of China (NO. 31420103915) and Chongqing Health and Family Planning Commission Project (2015MSXM012). We have no conflict of interest.