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Effect of Dose Calculation Grid Resolution On the Dose Uncertainty for High Definition MLC

J Kim*, A Chu , Z Xu , Stony Brook University, Stony Brook, NY


(Sunday, 7/29/2018) 3:00 PM - 6:00 PM

Room: Exhibit Hall

Purpose: 1) To present a clinical brain case where the dose distribution calculated at 2.5 mm grid resolution was significantly different from that of 1.0 mm with Varian HD120 MLC (2.5 mm central leaf width), and 2) to present our analysis results to better understand the influence of dose calculation grid resolution and its spatial alignment with MLC.

Methods: A simulation using a static MLC pattern with ten open strips was conducted to demonstrate the possibility that the characteristics of MLC dose profiles can be completely hidden. The effects of the spatial MLC alignment with the dose grid was investigated up to 2.5 mm. Lastly, twenty recent stereotactic radiotherapy plans (5 brain, 5 lung, 5 spine, and 5 other) were retrospectively selected and their dose distributions were recalculated at 1.0 mm, 1.5 mm, and 2.5 mm resolutions for comparisons.

Results: At 2.5 mm grid resolution, the MLC open strip patterns were not visible in the dose distribution when the MLC leaf interspaces were at exact alignment with the dose grid. Such adverse effect did not occur with 1.0 mm grid resolution. The dose at the centers of the open strips varied significantly (28%-43%) depending on the alignments. Overall, the PTV mean dose of 1.5 mm grid plans was higher than 1.0 mm grid plans by 1.3 ± 0.3 % (mean ± 1SD) with a maximum of 2.6%, while the mean dose of 2.5 mm grid plans was lower by -0.5 ± 0.5 % with a maximum mean dose of -3.7%.

Conclusion: The choice of dose calculation grid resolution can affect the plan dose distribution significantly. The dose grid resolution must be smaller than the width of MLC leaf at a minimum. A finder resolution is expected to produce less uncertainty in the calculated dose distributions, being less susceptible to the MLC–grid spatial alignment effect.


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