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Detection of Microcalcifications Using Spectral Breast CT

F BIRORI1*, W BARBER2 , D SENNUNG3 , H Ding4 , S Molloi5 , (1) University of California, Irvine, CA, (2) RAPISCAN SYSTEMS, Northridge, CA, (3) University of California, Irvine, CA, (4) Therapy Physics, Inc., Signal Hill, CA, (5) University of California, Irvine, CA


(Tuesday, 7/31/2018) 10:30 AM - 11:00 AM

Room: Exhibit Hall | Forum 6

Purpose: To investigate the detectability of microcalcifications in postmortem breasts using a benchtop prototype breast CT system based on energy-resolved silicon (Si) strip photon-counting detector.

Methods: A benchtop prototype breast CT system composed of a rotating scanning stage, a single line 1024-pixels Si strip photon-counting detector with a 100 µm x 100 µm pixel size, and a stationary X-ray source with 0.4 mm focal spot size and 3 mm aluminum filtration was used to image a postmortem breast with a diameter of approximately 12 cm. Simulated breast lesions with approximate size of 2 x 1 x 0.5 cm³ were made from lean tissue and microcalcifications of known size. The simulated lesions were then inserted into the postmortem breast and subsequently imaged at 65 kV and 2.3 mA. A helical scan was first performed to locate the axial position of the lesion within the postmortem breast. Axial scans with 100 µm slice thickness were done at the located position with the scanning stage rotating at 1 revolution/minute with each revolution generating 1200 projections. The mean glandular dose (MGD) was calibrated to be 6 mGy at these settings. The axial scan images were reconstructed using filtered back projection (FBP).

Results: Microcalcifications of at least 160 µm in diameter were successfully detected in postmortem breasts using the prototype spectral breast CT system at a MGD of 6 mGy.

Conclusion: The prototype spectral breast CT system was capable of detecting at least 160 µm microcalcifications at a MGD of 6 mGy.


Not Applicable / None Entered.


IM- Breast x-ray Imaging: Breast CT

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