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Advances in Novel Prototype Imaging Systems

M Bernstein1*, J Karp2*, K Li3*, W Zbijewski4*, (1) Mayo Clinic, Rochester, MN, (2) University of Pennsylvania, Philadelphia, PA, (3) University of Wisconsin-Madison, Madison, WI, (4) Johns Hopkins University, Baltimore, MD


(Tuesday, 7/31/2018) 1:45 PM - 3:45 PM

Room: Room 202

This imaging symposium aims to present the recent developments of four novel prototype imaging systems. Compared with standard clinical imaging systems, these prototype systems have demonstrated strong potentials in improving the imaging sensitivity, reducing ionizing radiation exposure, or enabling new clinical applications. Unlike laboratory benchtop-based systems, these prototype systems were designed and constructed to be clinically compatible, so that the medical utilities of the employed state-of-the-art MRI, PET, mammography, and cone beam CT technologies could be directly evaluated through human subject studies.

Dr. Bernstein will present the system developments of a compact 3T MRI prototype scanner with high performance gradients. He will talk about the application of this system in improving the assessment of brain tumor, stroke, and Alzheimer’s disease, as well as special considerations like geometrical accuracy, which is of particular importance for radiation therapy planning.

Dr. Karp will talk about both technical and clinical motivations for developing the total body PET system, followed by a brief review of the major technical challenges of total body PET imaging. In addition, Dr. Karp will present enabling technologies developed by his group, including time-of-flight methods, novel PET detector designs, etc., to address the technical challenges and achieve total body PET imaging.

Dr. Li will talk about the recent developments of a prototype multi-contrast (phase, dark field, and absorption) x-ray breast imaging system. He will present the motivation for developing such a clinically-compatible system, and describe how to modify a standard full field digital mammography scanner into such a prototype system.

Dr. Zbijewski will talk about dedicated extremity cone-beam CT (CBCT). He will discuss clinical motivation in imaging of joint disease, bone disease, and trauma, and present recent technical advances. Extremity CBCT was initially proposed to complement radiography by delivering point-of-care volumetric imaging with the unique capability for 3D weight-bearing evaluation of joints. Recently, new prototype systems were developed to support quantitative high-resolution imaging of bone health. The talk will present the underlying hardware and algorithms, initial results generated from a prototype CMOS-based system, and ongoing development of new image analysis algorithms for applications in quantitative assessment of bone.

Learning Objectives:
1. To understand the clinical motivations of developing the four prototype systems;
2. To recognize the major technical requirements and challenges for the developments of the four prototype systems;
3. To learn the key enabling technologies for each of the four prototype systems;
4. To understand the major differences between these novel prototype systems and the corresponding conventional systems (e.g., compact 3T MRI vs. conventional 3T MRI).

Funding Support, Disclosures, and Conflict of Interest: Research support: NIH R01EB020521; DOD Breakthrough Award W81XWH-16-1-0031



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