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Tumor Estimation Using Computational Biopsy Technique

X Qian1*, S Wang 2 , (1) Northwell Health, New Hyde Park, NY, (2) Saint Alphonsus Cancer Care Center, Boise, ID


(Sunday, 7/29/2018) 3:00 PM - 6:00 PM

Room: Exhibit Hall

Purpose: A computational optical biopsy system has been developed to detect and quantify an optical source deep in a homogeneous tissue medium by quickly determining tissue optical properties, such as absorption coefficient and transport scattering coefficient.

Methods: Diffuse light was collected by an optical fiber based needle with a detecting window at the end of it. The position and orientation of the detecting window of the needle detector were controlled by a 3D tracking system and a rotary stage. During measurements, the detected signals were recorded using a high-speed data acquisition system. To test the ability of this algorithm to accurately reconstruct the features of an optical source deep in a homogeneous tissue medium, measurements were performed in an aqueous suspension of 5.5L 3% Liposyn-10% tissue simulating phantom. The current method is effective for samples whose optical properties satisfy the requirement of the diffusion approximation.

Results: The results from both experiments and diffusion approximation simulations reasonably matched. The results from experiments were slightly greater than those from diffusion approximation simulations. In diffusion approximation simulations, only light within the maximum incident angle of the detecting window can be counted. In experiments, for those signals were initially outside of incident angle might be scattered back into the detectable region of the detecting window. However, since the optical source was weak and the reduced scattering coefficient was big, the difference between the results from diffusion approximation simulations and experiments were not significant. According to the above comparison, diffusion approximation seems adequate for estimation of the source features using this technique.

Conclusion: Our results indicate that the custom designed computational optical biopsy system has a potential for tumor sensing in fluorescent applications on patients.


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