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Enhancement of Radiosensitivity of Melanoma Cells by Pegylated Gold Nanoparticles Under Irradiation of Megavoltage Electrons

M Mosavi1 , H Nedaie2*, S Khoei3 , (1) Tehran University of Medical Sciences, Tehran, Tehran, (2) Radiotherapy Oncology Research Centre, Cancer Institute, Tehran University, Tehran, Tehran, (3) Iran University, Tehran, Tehran


(Sunday, 7/29/2018) 3:00 PM - 6:00 PM

Room: Exhibit Hall

Purpose: Gold nanoparticles (GNP) have significant potential as radiosensitizer agents due to their distinctive properties. Several studies have shown that the surface modification of nanoparticles with methyl polyethylene glycol (mPEG) can increase their biocompatibility. However, the present study investigated the radiosensitization effects of mPEG-coated GNP (mPEG-GNP) in B16F10 murine melanoma cells under irradiation of 6 MeV Electron beam.

Methods: The synthesized GNP were characterized by UV-Visible spectroscopy, dynamic light scattering, transmission electron microscopy, and zeta potential. Enhancement of radiosensitization was evaluated by the clonogenic assay at different radiation doses of megavoltage electron beams.

Results: It was observed that mPEG-GNP with a hydrodynamic size of approximately 50nm are almost spherical and cellular uptake occurred at all concentrations. Both proliferation efficiency and survival fraction decreased with increasing mPEG-GNP concentration. Furthermore, significant GNP sensitizationoccurred with a maximum dose enhancement factor of 1.22 at a concentration of 30 lM.

Conclusion: Pegylated-GNP are taken up by B16F10 cancer cells and cause radiosensitization in the presence of 6MeV electrons. The radiosensitization effects of GNP may probably be due to biological processes. Therefore, the underlying biological mechanisms beyond the physical dose enhancement need to be further clarified.


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