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Application of a Simple Optimisation Method in Intensity-Modulated Radiotherapy for Thymoma Postoperative

WZ Zhang, JY Lu, BT Huang*, Cancer Hospital of Shantou University Medical college, Shantou, Guangdong


(Sunday, 7/29/2018) 3:00 PM - 6:00 PM

Room: Exhibit Hall

Purpose: To explore the performance of a simple optimisation method: base dose function (BDF) in intensity-modulated radiotherapy (IMRT) for thymoma postoperative.

Methods: For 10 consecutive patients, two IMRT plans were created: 1)original IMRT plans (OIP), 2)the BDF plans (BDFP), in which were re-optimised based on the OIP. The dose-volume histogram (DVH) parameters, conformity index (CI), and heterogeneity index (HI) for PTV, organs-at-risk (OAR), and monitor units (MUs) were evaluated.

Results: The BDF plan (BDFP) generated a better D98 and CI, lower Dmean, D2 and HI for PTV than the original IMRT plans (OIP) (P<0.05). BDFP had lower Lung of V5, heart of V20, V30, V40, Dmean (P<0.05), but no significant difference in Spinal cord (SC) and planning risk volume for SC (PRV-SC) as compared with OIP. BDFP increaseed the monitor units (MUs) by 13% (P<0.05) than OIP.

Conclusion: All of the plans were clinically acceptable. Compared with OIP, BDFP showing better target coverage, part of OARs sparing, while MUs was slightly increased.

Funding Support, Disclosures, and Conflict of Interest: This work was sponsored by National Natural Science Foundation of China (No.81602667).


Not Applicable / None Entered.


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