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Construction of Realistic Hybrid Computational Fetus Models for Radiotherapy Applications

R Makkia1*, K Nelson2 , M Dingfelder3 , H Zaidi4 , (1) East Carolina University, Greenville, NC, (2) Vidant Medical Center, Greeville, NC, (3) East Carolina University, Greeville, NC, (4) Geneva University Hospital, Geneva, CH


(Sunday, 7/29/2018) 3:00 PM - 6:00 PM

Room: Exhibit Hall

Purpose: To accurately estimate the radiation dose to the fetus and assess the uncertainty of fetus position and rotation for a pregnant patient who is undergoing radiation therapy or diagnostic treatment.

Methods: Three computational phantom models were obtained using de-identified good quality MRI and CT imaging data for each fetus model as a starting point to construct a complete anatomically accurate fetus, gravid uterus, and placenta. All Radiological images in DICOM sets were obtained from Vidant Medical Center archive to conduct this study. The method started with outlines most of the fetus organs from radiological images via Velocity Treatment Planning System (TPS) and exported in the DICOM-STRUCTURE set which then was imported to Rhinoceros software, 3D model software for further reconstruction of 3D fetus phantom model sets. All fetus volume organs were adjusting to match ICRP-89 data record. After the models were finished, different fetus angles and locations were applied to represent fetus motion inside the uterus for each trimester of pregnancy with the guide of ultra sound images. Researchers have created a couple of computational fetus phantoms, but most of them have either been scaled to match certain weeks or lack of representing realistic models.However, no research has been done to show how the fetus angle and location may lead to uncertainty in dose calculations.

Results: A series of computational fetus models can be used to estimate the radiation dose to the fetus and evaluate the risk from radiation exposure due to a particular procedure.

Conclusion: This approach is demonstrating that fetus computational phantom sets are applicable to estimate the initial fetal organ doses. Newly developed fetus patient models provide realistic anatomical details that can be useful in treatment planning and ultimately risk assessment for the radiotherapy pregnant patients whose three-dimensional radiological images are not available.


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