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Education | IM | IM/TH | Leadership | TH | show all

Taxonomy: TH- External Beam- Photons: treatment planning/virtual clinical studies

MO-C930-GePD-F7-2Automated Treatment Planning for Whole Brain Irradiation with A Deep Learning Approach
E Han , C Cardenas , C Nguyen , M Amirmazaheri , T Briere , j Li , L Court , M Martel , Z Wen*, Unversity of Texas MD Anderson Cancer Center, Houston, TX
MO-C930-GePD-F7-3Deep Convolutional Neural Network Based Dose Prediction with Incorporation of Dosimetric Features From PTV-Only Treatment Plan
M Ma*, N Kovalchuk , M Buyyounouski , L Xing , Y Yang , Stanford Univ School of Medicine, Stanford, CA
MO-E115-GePD-F3-3Dose Distribution in the Near Zone of a CO2 Filled Breast Expander for 6MV and 10MV Photon Beams
B Hasson1*, T Li2 , C Geraghty3 , J Carroll4 , M Young4 ,(1) Anne Arundel Medical Center, Annapolis, MD, (2) ,Annapolis, MD, (3) Anne Arundel Medical Center, Annapolis, MD, (4) Versant Medical Physics & Radiation Safety, Tewksbury, MA, (5) Anne Arundel Medical Center, Annapolis, MD,
MO-E115-GePD-F7-3An Innovative Artifact Management Method for Proton Therapy Planning (AMPP) of the Head and Neck
D Branco*, P Taylor , S Kry , X Zhang , J Rong , S Frank , D Followill , UT MD Anderson Cancer Center, Houston, TX
MO-E115-GePD-F7-6Analysis of Spot Scanning Proton Verification Scan and Re-Plan Frequency
D Mundy1*, R Harper2 , N Deiter1 , (1) Mayo Clinic, Rochester, MN, (2) University of Minnesota, Minneapolis, MN
MO-I345-GePD-F7-2Enabling Patient Transfer From Millennium to HD MLC Varian Units; Feasibility Study of a Novel Workaround
H Afsharpour*, R Kaiyum, M Nielsen, K Bozzo, R Sankreacha, Peel Regional Cancer Center, Trillium Health Partners, Mississauga, ON
MO-I345-GePD-F7-3The Correlation Between Treatment Plan Dosimetry Metrics and the DICE Similarity Coefficient and Target Displacement, in a Prostate Cancer Treatment Planning Study
D Wang*, W Smith , M Phillips , University of Washington, Seattle, WA
MO-I345-GePD-F7-6Improving Pancreas SBRT Treatment Planning with PlanIQ
G Kuzmin1*, M Abazeed1 , M Kolar1 , A Magnelli1 , P Xia1 , S Balik1 , (1) Cleveland Clinic, Cleveland, OH
PO-GePV-M-10Dosimetric Impact of Forced Densities Over the Course of RT
D Schott1*, S Lim1 , R Thapa1 , D Prah1 , X Li1 , E Paulson1 , (1) Medical College of Wisconsin, Milwaukee, WI
PO-GePV-P-6Have Benchmarks and Pre-Treatment Reviews Impacted the Clinical Trial Deviation Rate?
J Lowenstein*, H Nguyen , J Roll , D Followill , UT MD Anderson Cancer Center, Houston, TX
PO-GePV-P-32Quantification and Impact Analysis of Planar MV Portal Images Cumulative Absorbed Dose On Head and Neck Radiotherapy Treatments
P Iwai*, C Marmitt , G Simonetti , Uniao Oeste Paranaense de Estudos e Combate ao Cancer, Parana, Brazil
PO-GePV-P-33Dosimetric Comparison Between Spinal SBRT Treatment Techniques Using IPlan and Elements SRS
C Venencia*, O Apaza , F Munoz , M Almada , Y Schworer , Instituto Zunino, Cordoba, ARGENTINA
PO-GePV-P-59Evaluation of Planning for Middle Thoracic Esophageal Carcinoma Based On Auto-Planning
M Miao , W Ma , R Zhang , Z Chi*, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei
PO-GePV-P-67Is Knowledge-Based Treatment Planning Depend On Treatment Machine and TPS?
X Chen*, J Wang , J Peng , J Wang ,
PO-GePV-P-80Plan Quality Comparison for Volumetric-Modulated Arc Therapy by Different Delivery Time for Non-Small Cell Lung Cancer
(1)L Dan*, Z Chi , j guo , X Han , Fourth Hospital of Hebei Medical University, Shijiazhuang, 13 (2) L Zhang ,Cangzhou Medical College,Cangzhou,Hebei
PO-GePV-P-81Comparative Analysis of Single Isocenter Versus Multi-Isocenter of Volumetric Modulated Arc Radiotherapy for Multiple Brain Metastatic From Lung Carcinoma
(1)L Dan*, Z Chi , j guo , X Han , Fourth Hospital of Hebei Medical University, Shijiazhuang, 13 (2) L Zhang ,Cangzhou Medical College,Cangzhou,Hebei
PO-GePV-P-83Efficiency of Auto Crop and Avoidance Structure Tools in Eclipse 15.5
F Zhang2*, (2) Bayhealth Medical Center, Dover, DE
PO-GePV-P-91Performance Assessment of Four Dose Calculation Algorithms for Spine SBRT
A Fernandez*, L Paredes , R Diaz Moreno , C Venencia , Instituto Zunino, Cordoba - ARGENTINA
PO-GePV-P-92Knowledge-Based RapidPlan Model for Prostate SBRT with and Without Lymph Nodes
O Apaza*, F Munoz , M Almada , A Alarcon , P Castro Pena , C Venencia , Instituto Zunino, Cordoba - ARGENTINA
PO-GePV-P-93Initial Experience Using Brainlab Elements Cranial SRS
C Venencia*, A Cardona , A Garcia , F Munoz , M Almada , P Castro Pena , S Zunino , Instituto Zunino, Cordoba - ARGENTINA
PO-GePV-P-96Evaluation of Intensity Modulated Radiation Therapy Planning for Cervical Cancer Based On Auto-Planning
R Zhang , Y Gao , W Bai*, M Mingchang , Z Chi , The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei
PO-GePV-P-105Improvement of Dose Distributions in Volumetric Modulated Arc Therapy (RapidArc) with Jaw Tracking Technique for Lateralized Target
R Diaz Moreno*, A Alarcon , O Apaza , L Paredes , C Venencia , Instituto Zunino, Cordoba - ARGENTINA
PO-GePV-T-71Towards CT Based Dose Calculation for Proton Beam Therapy of Ocular Melanoma: Calibration of a Serial Small Volume High Resolution CT Protocol to Match An Existing Proton Beam TPS Calibration Curve Combined with Atlas Based CT Artifact Reduction Method
M Mamalui*, R Dagan , M Rutenberg , Z Li , University of Florida/Radiation Oncology, Jacksonville, FL
PO-GePV-T-86Dosimetry Comparison of IMRT, VMAT Versus Proton and Carbon Ion Pencil Beam Scanning Techniques for Tongue Cancer
X Ming1*, K Shahnazi1 , L Kong1 , W Wang1 , (1) Shanghai Proton and Heavy Ion Center, Shanghai
PO-GePV-T-87Plan Quality Evaluation Using Simultaneous-Integrated Boost with Photon and Proton Therapy for Glioblastoma: An Initial Dosimetric Investigation Following NRG-BN001 Trial
T Cui*, B Liu , J Weiner , R Davis , R Parikh , K Nie , N Yue , Y Zhang , Rutgers Cancer Institute of New Jersey, New Brunswick, NJ
PO-GePV-T-91Pilot Study On Critical Structure Dosing for Ocular Melanoma Radiation Techniques: An Analysis of I-125 Brachytherapy Plaque and Dedicated Proton Eye Beamline Treatment Planning Dosimetry
J Scholey1*, V Weinberg1 , I Daftari1 , K Mishra1 , (1) University of California San Francisco, San Francisco, CA
PO-GePV-T-95Impact of Spot Position Errors for Three Optimization Algorithms in Spot Scanning Proton Therapy
Y Omi1*, N Hayashi2 , A Shimomura3 , K Yasui4 , T Nakanishi5 , (1) Graduate School of Fujita Health University, Toyoake, 23, (2) Fujita Health University, Tayoake, 23, (3) Nagoya Proton Therapy Center, Nagoya, 23, (4) Fujita Health University, Toyoake, 23, (5) Graduate School of Fujita Health University, Toyoake, 23
PO-GePV-T-97LET-Guided Planning Strategies for Localized Prostate Cancer in Proton Therapy
M Chen1,2*, P Yepes2,3 , W Cao2 , F Poenisch2 , Y Li2 , C Xu1 , X He1 , J Chen1 , N Sahoo2 , H Li2 , X Zhu2 , X Zhang2 , (1) Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China,(2) MD Anderson Cancer Center, Houston, TX, (3) Rice University, Houston, TX
PO-GePV-T-99Commercial Vs. In-House Developed Intensity-Modulated Proton Therapy Treatment Planning System for Advanced Stage Lung Cancer: A Treatment Planning Comparison
C Liu*, T Sio , J Shan , S Schild , T Daniels , T DeWees , Y Hu , X Ding , M Bues , W Liu , Mayo Clinic Arizona, Phoenix, AZ
PO-GePV-T-101Investigation of Appropriate Beam Spot Size for Pencil Beam Scanning Charged-Particle Therapy Incorporating Anatomical Heterogeneities
C Toramatsu*, Tokyo Women's Medical University School of Med.Tokyo T Inaniwa, National Institute of Radiological Sciences, Chiba, Japan T Nishio, Tokyo Women's Medical University School of Med.Tokyo K Karasawa*, Tokyo Women's Medical University School of Med.Tokyo
PO-GePV-T-103Evaluation of a Genetic Algorithm for Liver Treatment Planning in Proton Therapy
J Seo1, K Chung2 , S Ahn2 , B Lee2 , S Jeong2 , Y Jo1 , S Moon1 , M Yoon1*, (1) Korea University, Seoul, (2) Samsung Medical Center, Seoul
PO-GePV-T-112Examining the Impact of Beam Intersection Angles On CNS Toxicities in Pediatric Proton Therapy Patients
A Faught*, J Becksfort , T Merchant , J Lucas , St Jude Children's Research Hospital, Memphis, TN
PO-GePV-T-123Fast Aggregation of An Arbitrary Number of DVH Parameters Using Pinnacle On the Example of a Head and Neck Auto-Planning Study
F Exner , A Richter , S Weick , O Sauer*, University of Wuerzburg Department of Radiation Oncology, Wuerzburg, BY
PO-GePV-T-175Evaluation of Independent RapidPlan Models Based On Laterality of Secondary Nodal Disease for Head and Neck Cancer
L Taylor*, G Ezzell , E Silverstein , Mayo Clinic Arizona, Phoenix, AZ
PO-GePV-T-176Evaluation of 3D Vs IMRT Vs VMAT Planning Techniques for Obese Breast Cancer Patients: A Case Study
L Fu1*, A Yu2 , A Powers2 , Y Lo2 , (1) Mount Sinai West, New York, NY, (2) Mount Sinai Medical Center, New York, NY
PO-GePV-T-180GEUD Based Optimization Prevails Over Dose-Volume Optimizations: A Dosimetric Evaluation Study On NPC VMAT Cases
Y Shi*, h wang , h He , w xia , l wang , c ge , x yang , Bethune First Hospital of Jilin UniversityChangchun
PO-GePV-T-187A Dosimetric Comparison of Two Different Optimization Modes Used in Monaco Treatment Planning System During VMAT for Lung Cancer
S Chinnadaikkan1*, M Palanisamy1 , T Thangaraj1 , N Bhalla1 , A Puri1 , (1) Fortis Hospital, Department of Radiation oncology, Mohali, Punjab, India
PO-GePV-T-206Evaluation of IMRT Treatment of Thorax Esophageal Carcinoma in Elekta and Varian Linac
W Bai,R Zhang,Z Chi*,
PO-GePV-T-208Improving VMAT Prostate Plans by Multiple Reoptimizations
V Stakhursky1*, G Gejerman2 , M Ciccone2 , M Esposito2 , M Ahmed2 , M Goldstein2 , (1) New Jersey Urology Cancer Treatment Centers, Saddle Brook, NJ, (2) New Jersey Urology, Saddle Brook, NJ
PO-GePV-T-210Dosimetric Comparison of Treatment Plans for Comprehensive Chest Wall and Breast Cancers Using Precision and Multi Criteria Optimization in Ray Station
U Robins1*, C McKenzie2 , J Rizzo3 , A Gutierrez4 , (1) Miami Cancer Institute, Miami, FL, (2) Miami Cancer Institute, Miami, ,(3) RaySearch Americas Inc, New York, ,(4) Miami Cancer Institute, Miami, FL
PO-GePV-T-215Effect of Photon Energy On Whole Brain Radiation Therapy
A Licon*, S Stathakis , N Kirby , K Rasmussen , D Saenz , N Papanikolaou , P Myers , University of Texas HSC SA, San Antonio, TX
PO-GePV-T-227Treatment Planning Criteria and Evaluation for Pulsed Low Dose Rate Radiotherapy
C Ma1*, M Lin2 , J Li1 , S Kang1 , L Chen1 , R Price1 , (1) Fox Chase Cancer Center, Philadelphia, PA, (2) The University of Texas Southwestern Medical Ctr, Dallas, TX
PO-GePV-T-228The Influence of Large Training Sets Created with the Eclipse Scripting API in Custom RapidPlan Models
J Rogers*, M DiMascio , Atrium Health, Rock Hill, SC
PO-GePV-T-229Dosimetric Effects of Hip Replacement Implants On VMAT RT Plans for Prostate Cancer
V Stakhursky1*, M Goldstein2 , P Ciccone2 , B Schlecker2 , J Sanzone2 , G Gejerman2 , (1) New Jersey Urology Cancer Treatment Centers, Saddle Brook, NJ, (2) New Jersey Urology, Saddle Brook, NJ
PO-GePV-T-232Institutional Experience with Knowledge Based Planning for Patients with Rectal Cancer
A Dimofte*, P Irmen , J Marcel , R Wise-Payne , T Zhu , Univ Pennsylvania, Philadelphia, PA
PO-GePV-T-236An Innovative Approach to Overcome Limitations of External Beam Treatment Planning System to Implement Mixed Energy Photons with VMAT
S Awan*, R Badkul , H Saleh , M Jackson , A Tejwani , University of Kansas Hospital, Lawrence, KS Stormont Vail Hospital, Topeka, KS 66606
PO-GePV-T-240Evaluation of the Total Body Irradiation (TBI) Treatment Planning Using Eclipse
Q Zeng1*, Q Wu2 , (1) Duke Kunshan University, Kunshan, Jiangsu, (2) Duke University Medical Center, Durham, NC
PO-GePV-T-244Assessing the Performance of Automated Breast Treatment Planning Software
I Dragojevic1*, J Hoisak1 , R Manger2 , (1) UC San Diego, Chula Vista, CA, (2) UC San Diego, Encinitas, California
PO-GePV-T-246Uncertainty in Cardiac Dosimetry in Left Sided Breast Cancer: Effect of Grid Size
I Das1*, (1) NYU, Ambler, PA
PO-GePV-T-249The Effect of Calculation Grid-Size, Statistical Uncertainty and CT Slice-Thickness On Dose and Calculation Time for Monte Carlo(MC) and Collapsed Cone(CC) Algorithms in the Elekta Monaco Treatment Planning System
M Goss*, D Pavord , S Lee , H Lee , M Chetvertkov , S Oh , Y Liang , D Parda , J Sohn , Allegheny Health Network, Pittsburgh, PA
PO-GePV-T-250Surface Dose and Acute Skin Reactions in External Beam Breast Radiotherapy
P McDermott*, William Beaumont Hospital, Royal Oak, MI
PO-GePV-T-251Leaf Motion Calculator Effect On Sliding Window IMRT Field Complexity and Plan Quality
E Laugeman*, E Pryser , M Schmidt , F Reynoso , Washington University School of Medicine in St. Louis, St. Louis, MO
PO-GePV-T-358An Auto-Modified PTV Method to Improve Conformity for Single Isocenter Multiple Lesions SRS Conformal Dynamic Arc Plans
L Fu*, H Liu , Y Yu , Thomas Jefferson University, Philadelphia, PA
SU-F-221AB-8Virtual Non-Contrast Dual-Energy CT for Proton Therapy Dose Calculation
A Lalonde1*, Y Xie2 , B Burgdorf3 , S O'Reilly3 , W Ingram3 , L Yin3 , J Zou3 , L Dong3 , H Bouchard1 , B Teo3 , (1) Universite de Montreal, Montreal, QC (2) Massachusetts General Hospital, Boston, MA, (3) University of Pennsylvania, Philadelphia, PA,
SU-I300-GePD-F7-6Improving IMPT Delivery Efficiency by Increasing Minimum Spot MU in Plan Optimization
Mingyao Zhu, Katja Langen, University of Maryland School of Medicine, Maryland Proton Treatment Center, Baltimore, MD
SU-I330-GePD-F4-5Investigation of the Plan Quality for HyperArc Cranial Radiosurgery Using the Millennium MLC
E Flores-Martinez1*, G Kim2 , (1) Moores Cancer Ctr, Univ. of California, San Diego, La Jolla, CA, (2) University of California, San Diego, La Jolla, CA
SU-K-302-3Dosimetric Evaluation of Plans Utilizing Hydrogel for Rectum Sparing in Hypofractionated Prostate Radiotherapy
M Trager , C Fernandez , A Landers*, A Harrison , L Doyle , R Den , Thomas Jefferson University Hospital, Philadelphia, PA
SU-K-SAN4-4Comparison of Publicly-Available Knowledge-Based Planning Prostate Routines Using Automated Batch Planning
X Fave*, R Kaderka , S Hild , M Cornell , K Moore , Univ of California San Diego Moores Cancer Ctr, La Jolla, CA
SU-L-SAN4-1A Fully Automatic Solution of Treatment Planning for Rectal Cancer
X Xia*, J Wang , W Hu , Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, 31
TU-C1030-GePD-F1-2Comprehensive Assessment of Dosimetric Performance, Planning Efficiency and Risk of Secondary Cancers for MCO-VMAT Using 10-MV Versus 6-MV Photons
S Zieminski1*, C Cotter1 , I Kuo2 , A Zietman1 , K De Amorim Bernstein1 , J Wo1 , Y Wang1 , (1) Massachusetts General Hospital, Harvard Medical School, Boston, MA, (2) UMass Memorial Health Care, Worcester, MA
TU-E-SAN1-4Radiotherapy Dose Distribution Prediction Based On Patient Anatomy and Dose Volume Constraints
J Ma1*, D Nguyen2 , X Jia3 , W Lu4 , L Zhou5 , S Jiang6 , (1) UT Southwestern Medical Center, Dallas, TX, (2) UT Southwestern Medical Center, Dallas, TX, (3) University of Texas Southwestern Medical Center, Dallas, TX, (4) UT Southwestern Medical Center, Dallas, TX, (5) Department of Biomedical Engineering, Southern Medical University, Guangzhou, Guangdong, (6) UT Southwestern Medical Center, Dallas, TX
TU-E-SAN1-7Voxel-Wise Dose Prediction for Prostate Cancer Patients Using a Novel Machine Learning Model
P. James Jensen1*, Y. Sheng2, Y. Ge3, F. Yin1,2 , Q. Jackie Wu1,2 , (1) Duke University, Durham, NC, (2) Duke University Medical Center, Durham, NC, (3) University of North Carolina at Charlotte, Charlotte, NC
TU-F115-GePD-F7-1Clustering Based Dose Distribution Prediction Using Deep Convolutional Neural Network
M Ma*, M Buyyounouski , V Vasudevan , L Xing , Y Yang , Stanford Univ School of Medicine, Stanford, CA
TU-F115-GePD-F7-4Optimized Volumetric Modulated Arc Therapy (VMAT) Technique for Left Sided Breast Cancer Comprehensive Radiation Therapy Via the Halcyon Delivery System
S Goddu*, E Laugeman , J Hilliard , A Heermann , B Cai , S Mutic , G Hugo , I Zoberi , Washington University School of Medicine, St. Louis, MO
TU-HI-SAN1-1A Novel Plan-Quality Quantification Method Using K-Nearest-Neighbors Referencing
J Zhang1*, Q Wu2 , Y Ge3 , C Wang2 , Y Sheng2 , J Palta2 , J Salama2 , F Yin2 , J Zhang2 , (1) Duke Kunshan University, Kunshan, China, (2) Duke University Medical Center, Durham, NC, (3) University of North Carolina at Charlotte, Charlotte, NC
TU-HI-SAN1-6Real-Time Generation of Pareto 3D Dose Distributions for Radiotherapy
D Nguyen*, A Sadeghnejad Barkousaraie , C Shen , X Jia , S Jiang , Medical Artificial Intelligence and Automation (MAIA) Laboratory, Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, TX, USA
TU-HI-SAN1-8Dose Prediction with Deep Learning for Prostate Cancer VMAT Treatments
R Norouzi-Kandalan1,2*, D Nguyen1 , Z Trivedi1 , M Lin1 , A Barragan Montero3 , R McBeth1 , Q Yang1 , W Lu1 , k Namuduri2 , S Jiang1 , (1) UTSouthwestern Medical Center, Dallas, TX, (2) University of North Texas, Denton, TX,(2) Universite Catholique de Louvain, Brussels
TU-HI-SAN1-9Exploring Tradeoff Hyperplanes for Head and Neck Treatment Planning with a Knowledge-Based Model
J Zhang1*, Y Ge2 , Y Sheng1 , C Wang1 , Q Wu1 , F Yin1 , Q Wu1 , (1) Duke University Medical Center, Durham, NC, (2) University of North Carolina at Charlotte, Charlotte, NC
TU-J345-GePD-F1-3Dosimetric Comparison of RapidArc Photon and Pencil-Beam Scanning Proton Plans for Lung Stereotactic Body Radiation Therapy
M Parham1*, S Ahmad2 , H Jin3 , (1) University of Oklahoma | Health & Science Center, Midwest City, OK, (2) University of Oklahoma Health Sciences Center, Oklahoma City, OK, (3) University of Oklahoma Health Science Center, Oklahoma City, OK
TU-J345-GePD-F7-5An Approximate Policy Iteration Scheme for Beam Orientation Selection in Radiation Therapy
O Ogunmolu1*, A Sadeghnejad Barkousaraie1 , D Nguyen1, N Gans2 , S Jiang1 , (1) UT Southwestern Medical Center, Dallas, TX (2) The Universityof Texas at Dallas, Richardson, Dallas, TX
WE-C1000-GePD-F1-2Dosimetric Comparison of Several Radiotherapy Techniques in the Treatment of Scalp Cancer
D Schulze*, H Zhang , Northwestern Memorial Hospital, Chicago, IL
WE-C1000-GePD-F1-5Evaluation of VMAT Planning Strategies for Prostate Patients with Bilateral Hip Prostheses
D To1*, I Xhaferllari1 , M Liu1 , J Liang2 , C Knill3 , D Yan2 , S Nandalur1 , G Gustafson1 , D Lack1 , (1) Beaumont Health, Troy, MI, (2) Beaumont Health, Royal Oak, MI, (3) Beaumont Health, Dearborn, MI
WE-C1000-GePD-F7-2Investigation of Dosimetric and Radiobiological Impact of Setup Errors Using In-House "DVH Analyzer" for Carcinoma Cervix IIB Patients Treated with VMAT
A Tyagi1*, G Singh1,2 , R Srivastava1 , V Kumar2 , A Oinam3 , S Halder1 , S Hukku1, (1) Dr B L Kapur Memorial Hospital, New Delhi, (2) Centre for Medical Physics, Panjab University, Chandigarh, (3) PGIMER , Chandigarh
WE-C930-GePD-F2-1Development and Evaluation of a Machine Learning Optimization Model for Automatic Planning in Liver SBRT Using a Multicriteria Optimization Knowledge Base in RayStation
H Prichard*, J Wo, Y Wang, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
WE-C930-GePD-F3-5On the Use of 6MV-FFF Beam in the Treatment of Hypofractionated Left Breast Patients Using DIBH-CT
J Snyder*, J Molloy , M Bernard , D Pokhrel , University of Kentucky, Lexington, KY
WE-HI-301-4Atlas-Guided Fluence Initialization and Optimization for Pancreas SBRT: A Feasibility Study
W Wang1* , Y Sheng2 , C Wang2 , J Zhang2 , Y Ge3 , F Yin1,2 , Q Wu1,2 , (1) Duke University, Durham, NC, (2) Duke University Medical Center, Durham, NC, (3) University of North Carolina at Charlotte, Charlotte, NC