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  4. IROC Radiation Therapy QA Centers: 5 Years of Support of the NCI's NCTN Clinical Trials

IROC Radiation Therapy QA Centers: 5 Years of Support of the NCI's NCTN Clinical Trials

D Followill1*, J Michalski2 , T Fitzgerald3 , Y Xiao4 , (1) IROC Houston QA Center, Houston, TX, (2) IROC St Louis QA Center, Saint Louis, MO, (3) IROC Rhode Island QA Center, Lincoln, Rhode Island,(4) IROC Philadelphia QA Center, Philadelphia, PA

Presentations

(Sunday, 7/14/2019)  

Room: ePoster Forums

Purpose: The Imaging and Radiation Oncology Core (IROC) Cooperative has been active for the past five years supporting the National Clinical Trial Network’s clinical trials using radiation therapy.

Methods: Out of the six IROC QA centers, four centers (Houston, Philadelphia-RT, Rhode Island, and St. Louis) provide an integrated RT quality control program in support of the NCI’s NCTN clinical trials. These four centers have worked together for 20 years and have harmonized their support roles. Each QA Center’s efforts are focused on assuring high quality data for clinical trials designed to improve the clinical outcomes for cancer patients worldwide. This program is administered through five core services: site qualification, trial design support, credentialing, data management, and case review.

Results: IROC currently provides core support for 184 NCTN trials with RT, DI and RT/DI components. Many trials were legacy trials from the previous cooperative group program, but the majority are new NCTN trials. IROC monitors nearly 1850 RT photon and 26 proton institutions. Over 92,000 beams outputs were monitored with 7% of the sites requiring repeat audits. As part of RT credentialing 3419 QA phantoms were irradiated, 12,098 credentialing status inquiries were responded to and 10,831 RT credentialing letters were issued. In years 1-4 alone, 18,237 RT patient datasets were received (many using TRIAD) by IROC QA Centers to be prepared for review and a total of 15,406 RT cases were reviewed by IROC technical staff. To date, IROC has published or coauthored 94 manuscripts.

Conclusion: The QA services provided by IROC are numerous and are continually being evaluated for effectiveness, harmonized across all NCTN Groups and administered in an efficient and timely manner to enhance accurate and per protocol trial data submission. These efforts increase each NCTN Group’s ability to derive meaningful outcomes from their clinical trials.

Funding Support, Disclosures, and Conflict of Interest: Work was supported BY NCI grant CA180803

Keywords

Clinical Trials, Quality Assurance

Taxonomy

Not Applicable / None Entered.

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