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Potential of Using TiO2 Nanoparticles as a Contrast Agent in Computed Tomography and Magnetic Resonance Imaging

H Akasaka1*, N Mukumoto1 , R Yada2 , K Kyotani3 , K Okumura3 , M Miyamoto3 , T Wang2 , Y Shimizu2 , A Nakaoka2 , R Sasaki1 , (1) Division of Radiation Oncology, Kobe University Hospital, Kobe, ,(2) Division of Radiation Oncology, Kobe University Graduate School of Medicine, Kobe, ,(3) Center for Radiology and Radiation Oncology, Kobe University Hospital, Kobe


(Sunday, 7/14/2019) 3:30 PM - 4:00 PM

Room: Exhibit Hall | Forum 8

Purpose: Nanoparticles (NPs) have been studied extensively for their potential applications in the scientific field due to their unique electric, magnetic, and imaging abilities and their versatile functionality. Biomedical applications of NPs have attracted considerable attention because NPs are expected to improve medical diagnosis and treatment. Some NPs made of titanium dioxide have been investigated worldwide for their potential application in cancer therapy. Our previous study showed that the titanium peroxide nanoparticle has antitumor effect (Nakayama, 2016). In this study, we investigated the imaging abilities of TiO2-NPs using clinical CT scanning and MRI in an attempt to determine their image contrast properties.

Methods: The form of the TiO2-NPs was observed by Transmission Electron Microscope (TEM), and the size of the TiO2-NPs was measured by Dynamic Light Scattering (DLS). Various concentrations of TiO2-NPs were set, and imaging was performed using clinical CT and MRI, respectively, and the difference in visual capability was evaluated. The CT value, T1 relaxation time and T2 relaxation time were measured and compared with the literature value.

Results: Consistent with the TEM images, the diameter of the TiO2-NPs was determined to be approximately 50-100 nm using DLS. There were no differences between the CT value for the control group and for the different concentrations of TiO2-NPs used. As the concentration of the TiO2-NPs increase, T1 relaxation time do not change so much, however, T2 relaxation time changes markedly, especially at concentrations above 0.5 mg/mL.

Conclusion: The TiO2-NPs has considerable promise for use as contrast agent in MRI, especially T2-weighted MRI. Thus, it has the potential to be used as novel theranostic drugs with radiosensitizing and radiological diagnostic abilities. The findings of the present study indicate that TiO2-NPs may become a novel theranostic drug. Future clinical applications of those NPs require rigorous surface engineering and careful toxicity evaluation.


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