(Sunday, 7/14/2019)
Room: ePoster Forums
Purpose: Cutaneous radiation injury (CRI) can be an unfortunate consequence of radiation treatment, high-dose kV imaging, and other radiation exposures. A Monte Carlo model has been developed for a unique beta radiation device used in radiation skin injury studies, to enable study of the beta dose distribution at the skin surface as well as for dose assessment for morphological structures in the skin.
Methods: The geometry for a custom-made Sr-90 beta radiation device is modeled with the MCNP6 Monte-Carlo code, including steps for model validation. The skin is modeled to include a mathematical construct of a linear blood vessel of capillary size.. Simulation results are compared with experimental dose measurements and correlated with the spatial distribution of histological findings (epidermal necrosis and blood vessel thickening) for radiation skin injuries induced as part of an approved animal research protocol.
Results: Monte Carlo calculated results compare favorably with experimental dose measurements using radiochromic film and an extrapolation chamber and are consistent with the depth of injury observed in histological findings (epidermal and dermal necrosis, vasculature changes). Overall, the MC-calculated depth dose has been demonstrated to be deposited completely within the first 3 mm of the skin depth, with the majority of the dose being deposited in the epidermis and the first 2 millimeters of the dermal layers of the skin. Good correlation between the dose profile shape and the spatial distribution of epidermal necrosis is observed. The percent depth dose MCNP-simulated and experimentally measured results are provided along with the spatial distribution of the dose deposition across the irradiated site.
Conclusion: Monte Carlo simulation is an accurate representation of the beta radiation device as validated by the comparison to physical measurements and as such can be used for future beta devices development and investigation into radiobiological effects of beta radiation on skin.
Funding Support, Disclosures, and Conflict of Interest: Acknowledgement: This project has been funded in whole or in part with Federal funds from the Department of Health and Human Services; Office of the Assistant Secretary for Preparedness and Response; Biomedical Advanced Research and Development Authority, under Contract No. HHSO100201800022C.
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