(Tuesday, 7/16/2019) 1:15 PM - 1:45 PM
Room: Exhibit Hall | Forum 4
Purpose: The aim of this study was to calculate the NTCP by determining the radiobiological parameters n, m, TD50, γ50 from the fitted dose response curve
Methods: This is a single institutional prospective study of 43 patients of head and neck cancer which were available for mucositis & dysphagia toxicity analysis. There were 31 males and 12 females with median age of 59 years.Focal Sim Monaco (version 5.11) was used for contouring OARs and normal structures using RTOG guidelines of H&N cancer.Patients were evaluated weekly for acute radiation mucositis & dysphagia toxicity and scoring (Grading) as per CTCAE protocol.
Results: Acute radiation toxicity for oral mucosa in Carcinoma of H&N patients was calculated for the end point mucositis. The n, m and TD50, γ50 parameters for Grade 1 and Grade 2 mucositis from the fitted sigmoidal dose response curve are found to be 0.35,0.33, 23.40 (μ) ±1.17 (CI. 95%), 1.17 and 0.35, 0.22, 43.05(μ) ± 2.15 (CI. 95%), 1.72 respectively and average NTCP for Grade 1 and Grade 2 are found to be 95.94% ± 5.04 and 40.18% ± 20.78 respectively and for dysphagia n, m and TD50, γ50 parameters for Grade 1 and Grade 2 dysphagia from the fitted sigmoidal dose response curve are found to be 0.06,0.44, 22.46 (μ) ±1.51 (CI. 95%), 1.12 and 0.06, 0.22, 47.36(μ) ± 1.58 (CI. 95%), 2.37 respectively and average NTCP for Grade 1 and Grade 2 were found to be 98.37%± 1.25 and 74.23% ± 26.68 respectively.
Conclusion: This study presents the fitting parameters for NTCP calculation of Grade-I and Grade-II toxicities of mucositis & dysphagia in the H&N patients. Results showed the importance of radiobiological models based on the institutional data for the prediction of normal tissue toxicities which incorporates the socio-economic (health, environment and economic) conditions of the local patient.
Keywords
Not Applicable / None Entered.
Taxonomy
TH- Radiobiology(RBio)/Biology(Bio): RBio- LQ/TCP/NTCP/outcome modeling
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