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The Promise of FLASH

J Pollard-Larkin1*, L Dong2*, B Loo3*, (1) MD Anderson Cancer Center, Houston, TX, (2) University of Pennsylvania, Philadelphia, PA, (3) Stanford University, Stanford, CA


(Tuesday, 7/16/2019) 4:30 PM - 6:00 PM

Room: Stars at Night Ballroom 1

Ultra high radiation (FLASH) with dose rates greater than 40 Gy/sec has the potential to decrease normal tissue effects with an increase of tumor control (1). Evidence in the literature shows that FLASH lessens toxicity, such as memory loss in animals after whole brain irradiation. A FLASH device can be built by modifying a conventional linac as demonstrated recently by the Stanford group, achieving dose rate using such as device of >200 Gy/sec(3). This innovation enables access to such research device to centers interested in studying how FLASH radiation. FLASH has been recently become available on proton machines. Our symposium will cover the technical/physics, biological and clinical aspects of this new type of treatment.
1. Favaudon V, et al. Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice. Sci Transl Med 2014;245(6):1-9.
2. Montay-Gruel P et al. Irradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100 Gy/s. Radiother Oncol 2017;124(3):365-69.
3. Schuler E et al. Experimental Platform for Ultra-high Dose Rate FLASH Irradiation of Small Animals Using a Clinical Linear Accelerator. Int J Rad Onc Biol Phys 2017;97(1):195-203.

1.Understand the technical requirements and method for photon and proton FLASH treatments
2.Understand the biological basis of FLASH treatments
3.Understand the clinical applications of FLASH treatments



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