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Dosimetry in Radionuclide Therapy

R Hobbs1*, Y Dewaraja2*, B Bednarz3*, (1) Johns Hopkins University, Baltimore, MD, (2) University of Michigan, Ann Arbor, MI, (3) University of Wisconsin, Madison, WI


(Thursday, 7/18/2019) 11:00 AM - 12:00 PM

Room: Stars at Night Ballroom 4

Radionuclide Therapy (RNT) is fast becoming a mainstream modality with the development and approval of new emitters and conjugates. Along with the resurgence of interest in the radiopharmaceuticals themselves, there is a strong interest in the use of advanced methodologies for the calculation of absorbed radiation dose for patient treatment planning. Optimizing patient treatments by consideration of normal organ absorbed dose thresholds and/or tumoricidal absorbed doses using individual patient kinetics from 3D imaging (SPECT/CT and PET/CT) represents a safe and effective treatment strategy. The AAPM, ASTRO, SNMMI, IAEA, ICRU and the NCI have all expressed a strong desire to move in this direction and it is expected that patient specific, dosimetry-based treatment approaches become the norm in the near future, with a demand for qualified medical physicists to oversee and apply these methodologies. Here we present an overview of some of the more fundamental principles of RNT dosimetry with worked examples and presentation of different software available for use.

Learning Objectives:

1. Apply the Medical Internal Radiation Dose (MIRD) methodology.

2. Identify and use Monte Carlo-based RNT dosimetry commercial software.

3. Convert between RNT dose and 2-Gy fraction equivalent

4. Choose between and apply the different approaches for normal organ dosimetry vs. tumor dosimetry.



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