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Determining the Feasibility of Evaluating the Elastic Properties of Soft Tissues and Soft Materials by X-Ray Phase-Contrast Imaging

C Kamezawa1;2;3*, W Yashiro2 , A Yoneyama3 , K Hyodo4;1 , (1) SOKENDAI (The Graduate University for Advanced Studies), Tsukuba, , (2) Tohoku University, Sendai, ,(3) SAGA Light Source, Tosu, ,(4) KEK, Tsukuba,


(Sunday, 7/14/2019) 3:30 PM - 4:00 PM

Room: Exhibit Hall | Forum 8

Purpose: To improve the diagnosis of diseases, such as breast, liver, and thyroid cancer, we have been developing an x-ray elastography system with high spatial resolution using x-ray phase-contrast imaging.

Methods: In elastography, pressure or vibration is applied to a target site, and elasticity is imaged based on the mechanical response of the target site. We performed an experiment using 17.8 keV monochromatic x-rays from synchrotron radiation at the Photon Factory, KEK, Japan, and the world’s largest x-ray crystal interferometer. Among methods tested, phase-contrast imaging using an x-ray crystal interferometer yielded images with the highest density resolution (1 mg/cm3). Pig breast tissue in a polyethylene tube with an inner diameter of 10 mm was used to test x-ray elastography using the interferometer.

Results: By phase-contrast CT using the x-ray crystal interferometer, we could clearly visualize the inside of the sample with a spatial resolution of about 20 μm and high density resolution. By adding a vibration generator, we could visualize vibrations occurring inside the sample. We are planning to make a map of elastic modulus by analyzing the propagation of shear elastic waves inside the sample.

Conclusion: X-ray phase-contrast imaging could be used to evaluate the elastic properties of soft tissues and materials.

Funding Support, Disclosures, and Conflict of Interest: The part of this work was performed under the approval of the Photon Factory Program Advisory Committee (Proposal No. 2018T002). This research was supported by AMED under Grant Number JP17hm0102054.


Phase Contrast, X Rays


IM- X-ray: Development (new technology and techniques)

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