Room: Exhibit Hall | Forum 8
Purpose: To improve the diagnosis of diseases, such as breast, liver, and thyroid cancer, we have been developing an x-ray elastography system with high spatial resolution using x-ray phase-contrastã€€imaging.
Methods: In elastography, pressure or vibration is applied to a target site, and elasticity is imaged based on the mechanical response of the target site. We performed an experiment using 17.8 keV monochromatic x-rays from synchrotron radiation at the Photon Factory, KEK, Japan, and the worldâ€™s largest x-ray crystal interferometer. Among methods tested, phase-contrast imaging using an x-ray crystal interferometer yielded images with the highest density resolution (1 mg/cm3). Pig breast tissue in a polyethylene tube with an inner diameter of 10 mm was used to test x-ray elastography using the interferometer.
Results: By phase-contrast CT using the x-ray crystal interferometer, we could clearly visualize the inside of the sample with a spatial resolution of about 20 Î¼m and high density resolution. By adding a vibration generator, we could visualize vibrations occurring inside the sample. We are planning to make a map of elastic modulus by analyzing the propagation of shear elastic waves inside the sample.
Conclusion: X-ray phase-contrast imaging could be used to evaluate the elastic properties of soft tissues and materials.
Funding Support, Disclosures, and Conflict of Interest: The part of this work was performed under the approval of the Photon Factory Program Advisory Committee (Proposal No. 2018T002). This research was supported by AMED under Grant Number JP17hm0102054.