Room: AAPM ePoster Library
Purpose: The nonhuman primate (NHP) is the gold standard animal model for evaluating the response of human body to radiation exposure owing to similarities between its organ structure, genome, life span and metabolism. The combination of NHP and state-of-the-art molecular imaging technologies allow for within-subject, longitudinal research aimed at insight into the human condition and provide an ideal foundation for future translational studies of new therapies, medical procedures and diagnostics. However, radiation dosimetry estimations for nonhuman primates was rarely reported. The aim of this work is to develop computational models of nonhuman primates for radiation dosimetry.
Methods: A computational NHP model series with detailed skeleton structures were constructed based on non-uniform rational B-spline surface representations. Particle transport was simulated using Monte Carlo method. The absorbed fractions from monoenergetic photons and electrons, S values from radionuclides and absorbed doses from radiopharmaceuticals were calculated.
Results: For the developed NHP model, the average mass percentage of mineral bone is 7.2% and the average mass percentage of red bone marrow is 3.16%. For most source-target pairs in computational NHP models, the mean difference between considered S-values is about -10.5%/Kg difference in body weight. For the mineral bone and RBM, the absorbed dose of 18F-FDG in NHP models ranges from 0.051 mGy/MBq to 0.27 mGy/MBq and from 0.061 mGy/MBq to 0.34 mGy/MBq, respectively. Conversely, in 18F-FDG-based longitudinal studies, the cumulated absorbed dose of kidney ranges between 42 mGy and 47 mGy.
Conclusion: The developed NHP dosimetry database can be exploited for the assessment of radiation dose to NHP subjects in pre-clinical studies. The longitudinal research may cause innegligible cumulated radiation dose in crucial organs of laboratory animal and would result in steep secondary effects which might be a noteworthy issue in pre-clinical studies.
Funding Support, Disclosures, and Conflict of Interest: This study was supported by a start-up grant from Fudan University to T.X., the Swiss National Science Foundation under grant SNFN 320030_176052, Qatar national research fund (NPRP10-0126-170263) and the National Key R&D Program of China (Grant no. 2016YFF0200804).