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Cherenkov Imaging of TSE - An Evaluation of Dose Distribution Uniformity

T Zhu1*, T Miao2, X Chang1, Y Ong1, A Dimofte1, A Maity1, J Plastaras1, P Bruza2, L Dong 1, B Pogue2, (1) University Pennsylvania, Philadelphia, PA, (2) Dartmouth College, Hanover, NH


(Wednesday, 7/15/2020) 11:30 AM - 12:30 PM [Eastern Time (GMT-4)]

Room: Track 2

Purpose: Total Skin Electron Therapy (TSET) utilizes high-energy electrons to treat cancers on the entire body surface. The otherwise invisible radiation beam can be observed via the optical Cherenkov photons emitted from interaction between the high-energy electron beam and tissue.

Methods: Using a specialized camera-system, the Cherenkov emission can thus be used to evaluate the dose uniformity on the surface of the patient in real-time. Each patient was also monitored during TSET via in-vivo detectors (IVD) as well as Scintillators. Patients undergoing TSET in various conditions (whole body and half body) were imaged and analyzed.

Results: Perspective calibration was studied in 2D for Cherenkov imaging using a flat panal light source with proper correction and applied to acquired patient data. The patient studies showed that Cherenkov agreed to within 5% for most of the patients compared to the in vivo dose measurements. The Cherenkov intensity can be converted to dose by normalizing to IVD and/or Scintillators at the same location. Dose uniformity for 20 patients are analyzed.

Conclusion: Cherenkov imaging provides valuable information about the dose distribution for TSET.

Funding Support, Disclosures, and Conflict of Interest: Author Brian Pogue disclose that they are employed by the company DoseOptics LLC. Author Petr Bruza has sponsored research financially supported by DoseOptics LLC, through his employment at Dartmouth College. The authors would like to acknowledge funding support from NATIONAL CANCER INSTITUTE: 1R21CA239127-01A1.


Optical Imaging, Image-guided Therapy, Total Skin Irradiation


Not Applicable / None Entered.

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