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Study of Human Placenta Function Using MR Based Blood Oxygen Level Dependent (BOLD) Imaging

Y Zhou1*, Y Le1,R Kedar2,A Odibo3 (1) Department of Radiology, Mayo Clinic Arizona, Phoenix, AZ (2)Department of Radiology, University of South Florida, Tampa FL (3) College of Medicine Obstetrics & Gynecology, University of South Florida, Tampa FL

Presentations

(Sunday, 7/12/2020)   [Eastern Time (GMT-4)]

Room: AAPM ePoster Library

Purpose:
The goal of our study is to establish the feasibility of measurement of human placental blood oxygenation using blood oxygen level dependent (BOLD) MR imaging technology.

Methods:
A multi-echo GRE T2* sequence with 16 echoes was used to acquire BOLD images in 16 singleton pregnancies on a GE 3.0 Tesla system (GE Healthcare, Milwaukee, USA). An 8-channel body array coil was used for signal reception. All the subjects were scanned while breathing air followed by medical oxygen (100% O2) at a flow rate of 15 L/min with a face-mask. T2* maps were reconstructed by the exponential curve fitting with the multi-echo data on a pixel-by-pixel basis. Regions of interest (ROIs) were drawn covering the entire placenta on one slice where there is no abnormal structure observed.

Results:
Heterogeneity has been observed in the T2* quantitative map. The T2* averaged over all 16 subjects was found to have values of 41.3 ± 10.5ms, and 52.7± 17.0 ms between normoxia and hyperoxia, respectively. The T2* values ranged from 23.1ms to 59.1ms, and 29.9ms to 99.0ms in these 16 placentas between normoxia and hyperoxia, respectively.

Conclusion:
This study has demonstrated that BOLD MRI is a technology that can detect local variations in oxygenation for human placenta. Significant different T2* values have been found in the human placenta between breathing Air and Medical Oxygen. Quantitative T2* maps have been established using BOLD MR imaging technique. These quantitative values of human placenta will significantly enhance understanding of both normal microvascular development and its dysfunction leading to fetal growth restriction (FGR).

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