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Joint EFOMP/AAPM Symposium - Total Body PET: The Ultimate Molecular Imaging Tool

S Cherry1*, J Karp2*, T Jones3*, A Lammertsma4*, (1) University of California-Davis, Davis, CA, (2) University of Pennsylvania, Philadelphia, PA, (3) University Of California, Davis, GB, (4) Amsterdam University Medical Center, Amsterdam, NL


(Thursday, 7/16/2020) 10:30 AM - 12:30 PM [Eastern Time (GMT-4)]

Room: Track 1

Positron emission tomography (PET) is the most sensitive and versatile technique to image and quantify molecular processes in the human body. In most cases quantification requires dynamic scanning and, therefore, measurements are restricted to the axial field of view (FOV) of the scanner, which for most conventional state-of-the-art scanners is of the order of 25 cm thereby enabling the study of a single organ. Recently, so-called Total Body PET scanners have been developed with an extended field of view up to 2 m.

In this session first an introduction of total body PET will be given, illustrating the difference with conventional whole body PET. This will also include a discussion of the possibilities of the major increase in sensitivity due to the increased axial length and the challenges in handling the increased dataset sizes. The first part will be completed by reviewing existing systems (uEXPLORER and PennPET EXPLORER) together with some examples of studies that are possible on these systems.

Next, future developments in scanner design will be presented, such as a discussion on the optimal axial length, the relative gain from time-of-flight (effective sensitivity) vs higher statistics, the importance of other key factors such as spatial resolution, other concepts for detectors such as BGO and plastic, and novel concepts of scanner design such as axial gaps to increase the axial FOV without increasing costs.

The session will continue with an overview of projected applications of Total Body PET across internal medicine in both clinical research and healthcare.

Finally, the session will be concluded by a discussion of challenges and opportunities in (kinetic) data analysis of dynamic TB PET scans.

Learning Objectives:
1. Understand the principles and state-of-the-art of Total Body PET.
2. Understand design characteristics and strategies for optimising performance of Total Body PET.
3. Understand what type of clinical applications are uniquely possible with Total Body PET.
4. Understand about challenges and opportunities of Total Body PET data analysis.

Funding Support, Disclosures, and Conflict of Interest: Simon Cherry: Research agreement with United Imaging Healthcare Research collaboration with Canon Medical Research Unit Joel Karp: Research contract with Philips Healthcare Research contract with Siemens Healthcare Terry Jones: Research agreement with United Imaging Healthcare Adriaan Lammertsma: Nothing to disclose



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