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Image Guidance for Therapeutic Ultrasound

K Haworth1*, R Jones2*, S Schoen3*, R Chopra4*, (1) University of Cincinnati, Cincinnnati, OH, (2) Sunnybrook Health Sciences Centre, Toronto, ON, CA, (3) Georgia Institute of Technology, Atlanta, GA, (4) UT Southwestern Medical Ctr at Dallas, Dallas, TX


(Monday, 7/13/2020) 1:00 PM - 2:00 PM [Eastern Time (GMT-4)]

Room: Track 4

Therapeutic ultrasound has been gaining traction as a means to ablate tissue and enhance the delivery of therapeutics. Because of the noninvasive manner in which therapeutic ultrasound is applied, imaging is required for pre-treatment planning, peri-treatment guidance and monitoring, and post-treatment assessment of efficacy. The choice of imaging modality depends on the intended therapeutic mechanism of action. Absorption of ultrasound energy over time heats tissue to achieve effects ranging from mild hyperthermia to ablation. Thermal therapeutic ultrasound devices are coupled with MRI to enable real-time feedback on treatment progress with thermometry sequences. Acoustic cavitation is the most prominent mechanical effect induced by ultrasound for therapeutic purposes. Acoustic emissions generated by cavitation are an effective means to monitor cavitation-based therapies, and can be detected with standard ultrasound arrays and arrays integrated into the therapeutic ultrasound source.

This session will provide an overview of the mechanisms of ultrasound as a therapeutic modality. The use of imaging systems to guide the therapeutic insonation will be discussed. Standard and novel methods for image guidance of therapeutic ultrasound will be introduced, including the relevant imaging metrics to gauge therapeutic efficacy.

Learning Objectives:
1. Understand the origin of ultrasound-based therapeutic mechanisms
2. Understand the sequences used for MR thermometry, and how temperature is used for feedback during thermal ablation
3. Recognize the origin of cavitation-generated acoustic emissions, and how the emissions are processed to monitor cavitation-based therapies



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