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Pre-Clinical Assessment of HDR Eye Plaque Treatment Using a Monte Carlo-Based Treatment Planning System

D Aramburu Nunez1*, M Antaki2, M Morcos3,S Huang1 S Abbasinejad Enger2, C Barker1, A Damato1, G Cohen1, (1)Memorial Sloan Kettering Cancer Center ,New York, NY, (2) McGill University, Montreal, ,CA, (3)Johns Hopkins University, Baltimore, MD,


(Sunday, 7/12/2020)   [Eastern Time (GMT-4)]

Room: AAPM ePoster Library

Purpose: assessed the feasibility of HDR Ir-192 brachytherapy treatment of patients with choroidal melanoma using RapidBrachyMCTPS, a Monte Carlo-based treatment planning system.

Methods: preliminary design of a 20 mm gold eye plaque with four equidistant plexiglass catheters was made in Solidworks (2019) for HDR treatments. CT, structures, STL files were imported into the RapidBrachyMCTPS(1), following TG-129 recommendations(2). Three simulations, each with 100,000 histories using a 10 Ci GammamedPlus source model at different positions in the right eye of a dummy patient were performed. Each history started with the radioactive decay of Ir-192. The standard COMS prescription dose of 85 Gy was converted to an equivalent single fraction dose for Ir-192 HDR treatment of 35 Gy. Uniform and optimized dwell times were used to calculate 35 Gy to 8 mm depth from the center of the plaque. Dosimetric parameters were analyzed for ipsilateral and contralateral eyes, lenses, optic nerves, and lacrimals, as well as the chiasm and brainstem, contoured by physicians and planners.

Results: to critical structures were obtained. Specifically, the range of max dose over 3 simulations for the ipsilateral eye and, lens was 79.9 Gy - 103.7 Gy, and 18.3 Gy to 26.5 Gy, respectively. For the contralateral lens, chiasm, and brainstem the max dose range was 0.59 Gy - 0.99 Gy, Gy 0.99 - 1.19 Gy, and 0.38 Gy - 0.58 Gy, respectively. Dose profile calculations inside the treated eye were comparable to the ones showed by Luxton et al with LDR Co-60, I-125, and Ir-192 (3).

Conclusion: proof-of-principle study shows the clinical feasibility of treating choroidal melanoma patients using HDR Ir-192. HDR treatments can reduce the length of treatment and eliminate a second OR procedure for plaque removal. Further simulations using I-125 are needed to obtain an appropriate comparison of HDR Ir-192 treatments.

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Not Applicable / None Entered.


TH- Brachytherapy: Development (new technology and techniques)

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