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Feasibility of An Automated Clinical Workflow for Assessing Risk Organ Doses in Lung Re-Irradiation Patients Using EQD2

D Aramburu Nunez*, A Shepherd, X Li, A Wu, C Simone, A Rimner, A Jackson, L Santanam, E Yorke, Memorial Sloan-Kettering Cancer Center, New York, NY


(Sunday, 7/12/2020)   [Eastern Time (GMT-4)]

Room: AAPM ePoster Library

Purpose: assess cumulative organ doses after re-irradiations in SBRT lung patients using an automated clinical workflow in MIM that calculates both physical dose sum and EQD2 sum.

Methods: patient datasets, (CT, RTDOSE, RTSTRUCT, REG) from treatment courses 1 and 2, were exported from Eclipse to MIM. All patients had received one hypofractionated lung SBRT treatment plan at each course (prescriptions ranging from 7.5x8 – 18x3 (Gy x fx)). Rigid spine registration between Course 1 and Course 2 CTs (CT1 and CT2) was performed to transfer RTdose and RTstructures from CT1 to the reference set, CT2. Esophagus and Lungs were chosen for proof-of-principle, a union of the two esophagus structures was created as planning risk volume (PRVA MIM automated clinical workflow was created, calculating and displaying voxel-by-voxel physical dose-sum (PhyDose) and EQD2 dose-sum (a/ß = 3 for OARs). Dmax, and D5cc for esophagus_CT1, esophagus_CT2 esophagus_PRV, and mean doses and V20Gy for lungs from PhyDose and EQD2 dose-sums were compared. DICE similarity coefficients were calculated between Course 1 and Course 2 esophaguses displayed on CT2.

Results: to a low DICE between CT1 and CT2 esophaguses (0.5 ± 0.2), a PRV structure was created. The median (range) Dmax EQD2 for esophagus_PRV is 23.3 (12.2 – 97.1 Gy) and Dmax PhyDose 19.8 (11.8 – 38.8 Gy). Median (range) esophagus_PRV D5cc EQD2 is 12.4 (7.7 – 32.1 Gy) and D5cc PhyDose 13.1 (8.4 –21.1 Gy). Median (range) V20Gy EQD2 for lungs_CT2 is 12.8 (5.7 –24.4 %) and V20Gy PhyDose 10.0 (4.4 –20.5 %).

Conclusion: dose-sum volume histograms and EQD2-isodoses curves can provide more intuitive radiobiological information than physical dose-sum. A similar workflow can be used for other organs. A major limitation is that accurately including anatomical changes between courses will require deformable dose accumulation to confidently establish this automated workflow in the clinic.

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Not Applicable / None Entered.


TH- External Beam- Photons: treatment planning/virtual clinical studies

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