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Sensing Changes in Tumor During Boron Neutron Capture Therapy Using PET with a Collimator: Simulation Study

H Yang*, D Yoon, T Suh, The Catholic University of Korea, Seoul, KR


(Sunday, 7/12/2020)   [Eastern Time (GMT-4)]

Room: AAPM ePoster Library

Purpose: This study was aimed to demonstrate the feasibility of sensing changes in a tumor during boron neutron capture therapy (BNCT) using a Monte Carlo simulation tool.

Methods: An epi-thermal neutron source and a water phantom including boron uptake regions (BURs) were simulated in this study. Moreover, this simulation also included a detector for positron emission tomography (PET) scanning and an adaptively-designed collimator (ADC) for PET. After the PET scanning of the water phantom, including the 511 keV source in the BUR, the ADC was positioned in the PET’s gantry. Single prompt gamma rays were collected through the ADC during neutron irradiation. Then, single prompt gamma ray-based tomography images of different sized tumors were acquired by a four-step process. Both the signal-to-noise ratio (SNR) and tumor size were analyzed from each step image.

Results: The images acquired at each stage of the proposed treatment procedure in this study. As confirmed the obtained images, the diameters of the four BURs in the simulated virtual water phantom became smaller with the treatment time. From image analysis, we identified a decreasing trend of both the SNR and signal intensity as the tumor size decreased, which was confirmed in all images.

Conclusion: We confirmed the feasibility of sensing changes in a tumor during BNCT using PET and an ADC through Monte Carlo simulation.


PET, Capture Gamma Rays, Neutron Capture Therapy


Not Applicable / None Entered.

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