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Age Differences in Default-Mode, Executive-Control, and Salience Networks During Working Memory

L Zhang1, W Chai1, Z Qu1, Q Jiao1, W Cao1*, C Luo2, D Yao2, (1) Department of Radiology, Shandong First Medical University &Shandong Academy of Medical Sciences, Taian, 271016,China, (2) Key Laboratory for NeuroInformation of Ministry of Education, Center for Information in BioMedicine, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu,610041,China


(Sunday, 7/12/2020)   [Eastern Time (GMT-4)]

Room: AAPM ePoster Library

Purpose: investigate whether and how the interactions within and between the default mode network (DMN), executive control network (CEN) and salience network (SN) across working memory (WM) loads in older adults.
Methods: this study, 19 healthy older adults and 17 young controls underwent functional magnetic resonance imaging (fMRI) scanning during working memory task (1-back, 2-back). The 2 (between-subject factor: older and young groups) × 2 (within-subject factor: 1-back and 2-back) repeated analysis of variance (ANOVA) was used to examine the effects of aging on working memory performance. Functional connectivity analysis was employed to investigate the modulation of intra- and inter-network interactions across working memory loads. The educational level was controlled as a confounding feature in statistical analysis.
Results: with the controls, the older adults showed decreased accuracy and increased reaction time in two load WM task. The significant increased FCs intranetwork were observed in the three networks at higher WM load in older adults. The older adults showed increased FC between ventromedial prefrontal cortex (VMPFC) and posterior cingulate cortex (PCC) and cerebellar regions within the DMN, increased FC between the left dorsolateral prefrontal cortex (DLPFC) and right crus I (cerebellar regions) and between the left posterior parietal lobe (PPC) and right crus within the CEN, and increased left frontoinsula and right crus I at higher WM load. Lower FC strength of the PCC – PPC and the PPC- VMPFC of between the DMN and CEN was observed at higher load in the older adults compared with the controls.
Conclusion: results suggest that the changes of the integration intranetwork and the coupling internetwork might help the older adults’ response to cognitive demands at higher WM load. These findings may serves as a baseline for understanding the brain network mechanism of age-related WM impairment.

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Funding Support, Disclosures, and Conflict of Interest: This work was supported by the Funds of the National Natural Science Foundation of China (81901730 to Weifang Cao; 81371531to Qing Jiao), Science and Technology Project of the Education Department of Shandong province (J18KA262 to Weifang Cao).


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