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Study On the PET Radiomic Features of Myocardium in Patients Withesophageal Cancer Before and After Radiotherapy

X Sha*, G Gong, Y Yin, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences,Jinan,China.


(Sunday, 7/12/2020)   [Eastern Time (GMT-4)]

Room: AAPM ePoster Library

Purpose: aim of this paper is to investigate the changes of myocardial 18F-FDG positron emission computed tomography (PET) radiomic features in esophageal cancer (EC) patients before and after radiotherapy (RT).

Methods: patients with esophageal cancer who underwent 18F-FDG PET scan both pre-RT and 2 to 3 months after RT were enrolled in this study. We delineated left ventricular myocardium on 18F-FDG PET images as regions of interest (ROIs), then extracted metabolic parameters and texture features. Furthemore, we investigate the difference of these features in PET images before and after radiotherapy, and analyzed the correlation between metabolic parameters and texture parameters.

Results: hundred and seven features were extracted from each ROI, including 49 metabolic parameters and 58 texture parameters. Metabolic parameters, SUVmin, SUVmean, SUVpeak and SUVmax, decreased by 8.23%, 6.51%, 7.20% and 6.15% after RT, respectively. There were 6 texture features which performed statistically significant differences before and after RT, including second moment, entropy, busyness, low-intensity run emphasis, low-intensity long-run emphasis and correlation, and the change rates were-2.29%, -1.65%, 5.87%, 66.63%, 87.38% and 319.40%, respectively. Among them, the correlation characteristics with the largest change rate had the highest correlation with metabolic parameters, and the correlation coefficients were all higher than 0.5.

Conclusion: were significant differences in PET imaging characteristics of myocardium before and after RT, and the changes were greater than those of metabolic parameters. Quantifing these features is benefit for early detection and monitoring of radiation-induced heart injury.


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