Room: AAPM ePoster Library
Purpose: To build a custom micro-focus x-ray computed tomography (micro-CT) specifically for use in reducing positive margin rates in breast conserving surgery (BCS), which is adapted for integration of modulated light imaging in the ceiling of the chamber. Micro-CT systems have been used in pre-clinical, science & industry applications extensively, but have not been widely adopted into clinical use. In this development, a PerkinElmer system was custom built for an industry/academic partnership with Dartmouth-Hitchcock and Engineering at Dartmouth.
Methods: A dedicated system for BCS was built using the core of the IVIS SpectrumCT PerkinElmer system, adapted with flexible imaging installation for light projectors and cameras in the ceiling of the cabinet. Custom software was developed to control both the optical project and the micro-CT.
Results: A CMOS detector with 74.8 micron spatial resolution capable of imaging at 190fps and a source with maximum energy and current of 50kV and 1mA provide high contrast in breast tissue. The lateral micro-CT captures a field-of-view of 12cm diagonally and 3cm vertically, ideal for BCS specimens in size and pancake geometry. The ceiling of the self-shielded imaging chamber contains breadboard mounting for integration with optical components.
The majority of micro-CT software is engineering focused rather than clinically focused. This study has developed robust software that would have utility in a clinic. This was designed with speed in mind, a greater need in medical applications. CT reconstruction is performed using a GPU-based filtered backprojection algorithm for speed and accuracy of reconstructed volumes. This system is able to image and display a full reconstruction in under four minutes.
Conclusions: This project built a cabinet micro-CT system in a clinically feasible manner with software custom designed for ease-of-use by clinical staff and with clinical time constraints in mind. The cost is similar to specimen x-ray systems.
Funding Support, Disclosures, and Conflict of Interest: A number of authors are employed by PerkinElmer Inc.