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An Immuno-Oncology Primer for Physicists

J Schoenfeld1*, E Ford2*, J Jin3*, (1) Harvard/Dana-Farber Cancer Institute, Boston, MA, (2) University of Washington, Seattle, WA, (3) University Hospitals, Case Medical Center, Cleveland, OH


(Wednesday, 7/15/2020) 1:00 PM - 2:00 PM [Eastern Time (GMT-4)]

Room: Track 5

Emerging results from immuno-oncology (IO) trials are changing the standard of care in some disease sites. Radiation therapy plays a key role in many of these combined modality treatments and, as such, it is important for medical physicists to have a good working understanding of this topic. This session will provide an overview of this topic including a review of the fundamentals from an IO expert (“Immuno-101” in the RT context). It will also discuss emerging data on predictors of response in patients and the connection with radiation dose-timing effects. Finally the session will include a presentation of biophysical models for the impact of radiotherapy on the immune status of the host.

Learning Objectives:
1. Understand the fundamental biological underpinnings of the interaction between the immune response and radiation therapy.
2. Learn about emerging data connecting immune response to radiation dose and biophysical models that describe this interaction.
3. Appreciate how medical physicists might participate in IO efforts in the clinical and research space.



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