Room: AAPM ePoster Library
Purpose: High glucose levels has been linked to hippocampal and amygdalar volume reductions. However, the effects of the blood glucose level on hippocampal and amygdalar subregion volumes remain unclear, especially in the prediabetes stage.
Methods: Sixty-three participants were enrolled in this cross-sectional study and were divided into the type 2 diabetes group (male/female, 7/14), prediabetes group (male/female, 8/13), and normal controls (male/female, 7/14) according to their medical history and HbA1c level. FreeSurfer 6.0 software was used for the hippocampus and amygdalar parcellation. Hippocampal and amygdalar subregion volumes were adjusted by total intracranial volume (TIV). The general linear model (GLM) was used to analyze the volume changes, and age, gender and education were included as covariates. The indices with significant differences across the three groups were examined further by post-hoc differences. False discovery rate (FDR) correction was performed, and the significance level was set at 0.05.
Results: Reduced hippocampal and amygdalar subregion volumes were found in patients with prediabetes and those with T2D in the bilateral lateral molecular layer, cornu ammonis 1 (CA1), granule cell layer of the dentate gyrus (GC-DG) and the left CA2/3, left CA4, right Subiculum, right Fimbria (p < 0.05) and the bilateral lateral basal nucleus, lateral nucleus, accessory basal nucleus (ABN), cortico-amygdaloid transition area (CAT), and the left anterior amygdaloid area (AAA), left central nucleus, right cortical nucleus, right paralaminar nucleus (p < 0.05) compared with normal controls. No significant differences in hippocampal and amygdalar subregion volumes were found between participants with T2D and prediabetes.
Conclusion: Our results support that volumetric decline of hippocampal and amygdalar subregions may be served as an early marker of diabetes-related brain damage. Clinicians should pay closer attention to adults in the prediabetes stage to prevent later brain atrophy and cognitive impairment.
Funding Support, Disclosures, and Conflict of Interest: We are grateful for support from the Fundamental Research Funds for the Central Universities (3332018159),and the Academic promotion programme of Shandong First Medical University (No. 2019QL009). J. Q. was supported by the Taishan Scholars Program of Shandong Province (ts201712065).