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Single Snapshot X-Ray-Induced Luminescence Computed Tomography (SS-XLCT)

X Dai*, K Cheng , W Zhao , L Xing , Stanford University School of Medicine, Stanford, CA


(Wednesday, 7/17/2019) 10:15 AM - 12:15 PM

Room: 304ABC

Purpose: X-ray-induced luminescence computed tomography (XLCT) is an emerging molecular imaging. Challenges are still remaining for practical in vivo applications when short scan time, good spatial resolution, and whole-body field of view (FOV) are considered simultaneously. Here, we present a novel XLCT technique capable of obtaining volumetric images in a single snapshot to tackle these challenges.

Methods: In this study, a novel two-planar-mirrors component was integrated into a cone beam X-ray luminescence computed tomography imaging system to obtain multiple optical views of an object simultaneously, which significantly speeds up XLCT data acquisition. Moreover, a compressive sensing based three-dimensional (3D) XLCT image reconstruction algorithm was developed to improve the spatial resolution.

Results: Numerical simulations and experiments were conducted to validate our proposed single snapshot X-ray-induced luminescence computed tomography (SS-XLCT). The results show that the 3D distribution of the nanophosphor targets can be visualized at a speed of 20 times faster than conventional XLCT imaging while maintaining comparable spatial resolution as in conventional XLCT imaging.

Conclusion: A high-speed X-ray-induced luminescence computed tomography technique, namely, SS-XLCT, has been proposed and implemented to leverage the practical abilities of XLCT for in vivo molecular imaging. The results show that real-time XLCT can be achievable for in vivo small animal whole-body molecular imaging.


Tomography, Optical Tomography, X Rays


IM- Optical : Development (new technology and techniques)

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