Room: Exhibit Hall | Forum 3
Purpose: Cherenkov imaging analysis has been studied to analyze the relative dose distribution in total skin electron therapy (TSET). In this study, we introduce the workflow to analyze the Cherenkov intensity distributions over the entire skin surface of a TSET patient, using the 3D computer animation techniques. This workflow can provide a visual and accurate method to analyze the uniformity of dose delivered to the patientâ€™s skin.
Methods: The Cherenkov imaging acquisition system (C-Dose, DoseOptics LLC) was set up in the Linac treatment room to acquire the frames of Cherenkov intensity during electron irradiation. A structured light sensor (Structure sensor, Occipital) was positioned to extract the 3D mesh of the patientâ€™s different standing postures. A commercially-produced body mesh was used with editing to match the body contours acquired by the structured light sensor. The body mesh is rigged to a skeleton, allowing it to be moved into each of the 6 positions used in the Stanford TSET technique. The surface Cherenkov distribution in each body position was then mapped back to a standard skin surface called a UV texture map, allowing the doses from different positions to be added together on a single skin map.
Results: The body mesh can be made to accurately model the patientâ€™s body contour in different postures, and comparison to the surface indicates mean error of 3 cm in Hausdorff distance. The Cherenkov intensity distributions can be effectively projected onto the body shape, and the body shapes can be effectively maneuvered into the 6 stances used for treatment. Finally, the 6 dose maps can be accumulated from different sections of treatment by using texture mapping.
Conclusion: This study shows that this workflow of processing 2D Cherenkov intensity data in the patientâ€™s 3D body contour is powerful in both analyzing and visualizing the Cherenkov distribution.
Funding Support, Disclosures, and Conflict of Interest: This work has been sponsored by NIH research grant R01EB023909. B Pogue is the president and co-founder of DoseOptics LLC. P Bruza is the principal investigator in SBIR subaward B02463 (prime award NCI R44CA199681, DoseOptics LLC).