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Beam Angel Optimization Integrated with Knowledge-Based Planning to Further Spare Organs at Risk for Cervical Cancer

J Li*, C Tao , C Ma , T Liu , J Zhu , J Lu , Y Yin , Shandong Cancer Hospital Affiliated to Shandong University, Jinan, 37


(Sunday, 7/14/2019)  

Room: ePoster Forums

Purpose: In this study, beam angle optimization (BAO) was integrated with RapidPlan planning, a knowledge-based planning approach, to further spare organs at risk (OARs) for cervical cancer. The dosimetric advantages of this integrating solution were investigated.

Methods: 20 previous patients with cervical cancer were enrolled in this study. A RapidPlan DVH estimation model was established by previous 60 patients with clinical approved IMRT plans. IMRTn plan for each patient was generated by RapidPlan with 7 equispaced beams. The corresponding IMRTy plan, implemented the BAO and RapidPlan, was created as follow: firstly, constraints were predicted by the RapidPlan module with 7 equispaced beams; then, BAO were applied to generate 7 beams by the predicted constraints; at last, IMRTy plan was generated by RapidPlan planning with the selected 7 beams. And the dosimetric advantages of IMRTy plans was studied by comparing with the corresponding IMRTn plans.

Results: The coverage, homogeneity and conformity of PTV in IMRTy plans were comparable with IMRTn plans. For bladder, IMRTy plans produced lower V10, V40 and Dmean compared with IMRTn plans with significant differences (p=0.02, <0.01 and 0.01 for V10, V40 and Dmean, respectively). All dose/volume indices of femur head-L in IMRTy plans were lower than IMRTn plans without significant differences, except V40 (0.03 for IMRTy and 0.14 for IMRTn with p=0.04). Meanwhile, V30, V40 and Dmean of femur head-R produced by IMRTy plans were lower than IMRTn plans with significant differences (p=0.02, 0.04 and 0.03 for V30, V40 and Dmean, respectivly). IMRTy plans reduced all dose/volume indices of rectum compared with IMRTn plans with significant differences (p=0.02 for V10 and p<0.01 for other indices).

Conclusion: Beam angle optimization integrated with RapidPlan planning could more spare OARs with similar coverage, homogeneity and conformity of PTV, compared with RapidPlan planning with equispaced beams.


Not Applicable / None Entered.


Not Applicable / None Entered.

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