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Determining Relative T2 Relaxation Rates of Breast and Tibial Bone Marrow Fat Tissue with Magnetic Resonance Spectroscopy at 3T

C.J. Fallone1*, A. Yahya1,2 , (1) Department of Oncology, University of Alberta, Edmonton, AB, Canada (2) Department of Medical Physics, Cross Cancer Institute, Edmonton, AB, Canada


(Tuesday, 7/16/2019) 11:00 AM - 12:15 PM

Room: 221AB

Purpose: Magnetic Resonance Spectroscopy (MRS) can assess fat unsaturation in human adipose tissue by measuring olefinic to methylene peak area ratios. Long echo time (TE) MRS techniques were optimized (considering J-coupling evolution and Tâ‚‚ relaxation) for such measurements in tibial bone marrow at 3T. The objective of this work is to compare apparent (to indicate inclusion of J-coupling effects) Tâ‚‚ relaxation times of olefinic and methylene resonances in breast and tibial bone marrow at 3T to determine if previously optimized long-TE values for bone marrow can be applied to breast.

Methods: Spectra were acquired from breast and tibial bone marrow of 4 female volunteers using a 3T whole body MRI scanner and a Point RESolved Spectroscopy sequence, with varying TE values and repetition time of 3 s. Apparent methylene and olefinic resonance Tâ‚‚ relaxation times were calculated for each volunteer. The ratios of Tâ‚‚ relaxation times in breast to tibial bone marrow were computed for each resonance. A mean and standard deviation were calculated over the volunteers.

Results: Average apparent T₂ relaxation times were 83 ± 7 ms and 90 ± 4 ms (methylene resonance) and 36 ± 2 ms and 40 ± 5 ms (olefinic resonance) in breast and tibia, respectively. The average ratios (with standard deviations) of apparent T₂ relaxation times in the breast versus tibial bone marrow were 0.91 ± 0.12 (olefinic resonance) and 0.93 ± 0.11 (methylene resonance).

Conclusion: Apparent olefinic and methylene Tâ‚‚ relaxation times are about 8 % lower in breast versus tibial bone marrow. Because breast Tâ‚‚ values differ from those in tibial bone marrow by a similar amount, comparisons between olefinic to methylene ratios in breast and tibial bone marrow can be made without Tâ‚‚ compensation. Thus, the previously optimized long-TE values are also adequate for olefinic to methylene measurements in breast.


Relaxation Times, Breast, MRS


IM- MRI : Spectroscopy

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