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Comparing Biological Equivalent Dose of Large Cerebral AVM Treatment Schemes Using Universal Survive Curve

C Ding*, J Wang , S Jiang , UT Southwestern Medical Center, Dallas, TX


(Sunday, 7/14/2019)  

Room: ePoster Forums

Purpose: To compare the radiobiological dose of multi-stage SRS treatment planning technique to single fraction SRS and fractionated SRT treatment for large cerebrum AVM using universal survive curve.

Methods: An anthropomorphic head phantom with a centrally located large AVM (18.2 cm³) was included in this study. A total prescription dose of 20Gy was used for a single fraction SRS, three staged SRS and three fractionated SRT treatment. Cyber Knife treatment plans were optimized for the target volume to achieve at least 95% coverage of the prescription dose. For the multi-stage plan, the target was segmented into three sub-targets having similar volume and shape. Dose matrices for each plan were export in DICOM format and used to calculate biological equivalent dose distributions using universal survive curve.

Results: Singe fraction SRS, multi-stage plan and multi-fractionated SRT plans had an average Biological Equivalent Dose (BED) to the target of 85.31Gy, 69.64Gy and 67.90Gy, , respectively. The normal tissue within 50% of prescription physical dose region had an average BED of 62.65Gy, 35.9Gy, and 30.26Gy, respectively.

Conclusion: The multi-stage treatment provided increased biologically effect on target compared to the multi-fraction SRT treatments with less normal tissue toxicity than single-fraction SRS treatment.


Not Applicable / None Entered.


Not Applicable / None Entered.

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