Room: Exhibit Hall
Purpose: Our study is to fabricate individualized anthropomorphic phantoms with radiation attenuation properties using a cost-effective manufacturing process.
Methods: The phantom was constructed by Three Dimensional (3D) printing and perfusion modeling based on the individualized 3D model obtained from the chest Computed Tomography (CT) scans. Phantom contains a 3D-printed skin shell filled with tissue-equivalent anthropomorphic materials. Fat tissue consists of Mâ‚ƒ waxï¼ˆ87%ï¼‰, CaCOâ‚ƒ (1%) and MgO (12%); muscle tissue contains 2% agarose, 1% NaCl, and 0.8% pearl powder, and lung tissue is silica gel.
Results: In chest phantoms of CT imaging, the Hounsfield units of fat tissue range from about -60 to -100. The Hounsfield units of muscle tissue range from about 20 to 60, and the Horsfield units of bone range from about 120 to 300. 3D printing achieved a detailed anatomy, and materials could well simulate the CT values of the real body tissue. The tissue contrast can be shown clearly in imaging, and material attenuation coefficient is equivalent to the real body tissue. CT imaging of the chest phantoms shows highly similar to the real human CT image morphology.
Conclusion: The presented method enables customizable phantom fabrication for diagnosis and therapeutic purposes. The application of 3D printing in phantom fabrication can improve efficiency and reduce cost in growing need of personalized medicine.
Funding Support, Disclosures, and Conflict of Interest: Acknowledgement Fund Projects: National Key Research and Development Project (2016YFC0103400). J. Q. was supported by the Taishan Scholars Program of Shandong Province .