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Roles of RT in Immunotherapy

A Monjazeb1*, M Ahmed2*, C Grassberger3*, (1) University of California at Davis, Sacramento, CA, (2) National Cancer Institute/National Institutes of Health, Rockville, MD, (3) Massachusetts General Hospital, Boston, MA


(Wednesday, 8/1/2018) 1:45 PM - 3:45 PM

Room: Karl Dean Ballroom A1

The intrinsic genotype and phenotype structured tumor microenvironment keeps host immune surveillance in evasion. Recent advances in cancer immunology led to understand the mechanism of immune evasion by targeting the checkpoint expression proteins in tumors and T-cells. This breakthrough led to the development of checkpoint blockade therapy that resulted in several clinical trials including combining with radiation for various disease sites and yielded promising results. Combination trials with radiation plus immunotherapy showed mixed and dismal results as we are still learning from pre-clinical data and clinical trials.

Learning Objectives:
1. To provide an opportunity to the members of Medical Physics community to understand cancer immunotherapy concepts, the role of radiation changing the immune tumor microenvironment leading to bystander/abscopal events, understanding such radiation-induced immune modulating effects in a specific site disease and required rules in combining radiation plus immunotherapy.
2. To provide and focus on the primer in radiation and immune modulation, the biology of abscopal effects and partial volume radiotherapy, radiation and immunotherapy interaction modeling, non-invasive imaging of immune cell trafficking and effects of missed-target induced leucopenia in radiation-induced immune modulation and immunotherapy.



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