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Novel Molecular Imaging Techniques to Personalize Cancer Treatment

D Mankoff1*, Y Watanabe2*, S Achilefu3*, (1) Hospital of the University of Pennsylvania, Philadelphia, PA, (2) University of Minnesota, Minneapolis, MN, (3) Washington University School of Medicine, St. Louis, MO


(Wednesday, 8/1/2018) 4:30 PM - 6:00 PM

Room: Karl Dean Ballroom B1

Molecular imaging (MI) tools are increasingly being incorporated into cancer care as they provide important biologic information to complement standard anatomic imaging modalities. In today's era of personalized medicine, MI will serve a critical role in cancer diagnosis and in guiding patient-specific cancer treatment, including targeted drugs, radiation therapy, and surgical techniques.

In this multi-speaker session of MI experts, the concept of MI data as cancer biomarkers will be introduced. First, the role of PET cancer imaging and other molecular imaging approaches to identify cancer target expression, measure drug delivery to the target, assess early response to therapy, and predict patient outcome post-treatment will be examined. Novel tracers and applications of PET will be discussed, citing examples from clinical practice and ongoing clinical trials. Second, MI techniques specific to radiation therapy planning and monitoring of radiation treatment outcomes will be presented, with recommendations of proper and timely adaptation of MI tools to improve quality of care. Updates from the AAPM Working Group of Molecular Imaging in Radiation Oncology will be provided. Finally, an innovative MI technique with application in cancer surgery, Cancer Viewing Glasses (CVGs), will be presented. CVGs are designed to detect near-infrared fluorescence from molecular probes targeted to cancer cells and importantly, to operate under normal room light conditions which allows their use in a surgical suite. Results from mouse models and breast cancer patients showing promise for CVGs to improve surgical outcomes will be presented.

This session will provide an overview of the current role of MI in cancer and highlight innovations in the field that are poised to transform cancer treatment.

Learning Objectives:
1. Discuss the role of PET in guiding targeted cancer drug therapies.
2. Discuss the role of MI techniques in tailoring radiation therapy.
3. Recognize advanced optical imaging approaches for improving cancer surgery outcomes.



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